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Literature summary for 3.4.24.86 extracted from

  • Yin, J.; Yu, F.
    ERK1/2 mediate wounding- and G-protein-coupled receptor ligands -induced EGFR activation via regulating ADAM17 and HB-EGF shedding (2009), Invest. Ophthalmol. Vis. Sci., 50, 132-139.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
GW280264X blocks ADAM10 and ADAM17 activity similarly Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein in wounded cells, ADAM17 is phosphorylated at serine residues in an extracellular signal-regulated kinases ERK1/2-dependent manner Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell corneal epithelial cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparin-binding EGF-like growth factor + H2O ADAM17 may be involved in heparin-binding EGF-like growth factor cleavage in response to injury Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function ADAM17 is physically associated with active extracellular signal-regulated kinases ERK1/2 and is phosphorylated at serine residues in an ERK-dependent manner in wounded cells Homo sapiens