Literature summary for 3.4.24.86 extracted from

Sisto, M.; Lisi, S.; Lofrumento, D.D.; Frassanito, M.A.; Cucci, L.; DAmore, S.; Mitolo, V.; DAmore, M.
Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodies (2009), Int. Immunol., 21, 1341-1349.

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Application

Application	Comment	Organism
medicine	increased TACE activity is necessary for the release of TNF-alpha observed in anti-Ro/SSA antibodies-stimulated salivary gland epithelial cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	non-neoplastic salivary gland epithelial cells	Homo sapiens	-
salivary gland	non-neoplastic salivary gland epithelial cells	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	increased TACE mRNA expression in anti-Ro/SSA antibodies-treated salivary gland epithelial cells is restored to normal levels by Adalimumab treatment	down
Homo sapiens	dose-dependent increase of TACE mRNA expression in anti-Ro/SSA antibodies-treated salivary land epithelial cells, followed by internalization, pro-domain shedding and activation of TACE protein, suggesting that increased TACE activity is necessary for the release of TNF-alpha observed in anti-Ro/SSA antibodies-stimulated salivary gland epithelial cells. Adalimumab treatment brings TACE mRNA and surface TACE expression to levels similar to those observed in untreated salivary gland epithelial cells	up

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Release 2023.1 (January 2023)