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Literature summary for 3.4.24.86 extracted from

  • Sisto, M.; Lisi, S.; Lofrumento, D.D.; Caprio, S.; Mitolo, V.; DAmore, M.
    TNF blocker drugs modulate human TNF-alpha-converting enzyme pro-domain shedding induced by autoantibodies (2009), Immunobiology, 215, 874-883.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
anti-Ro/SSA autoantibody i.e. antinuclear autoantibodies in the blood directed against Ro/Sjögren's syndrome ribonucleoprotein A antigen. Adalimumab appears to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoantibodies Homo sapiens

Application

Application Comment Organism
medicine anti-Ro/SSA autoantibodies determine TACE pro-domain shedding suggesting that TACE activity is necessary for the release of TNF-alpha observed in anti-Ro/SSA autoantibody-stimulated cells. Adalimumab appears to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoantibodies. Regulation of TACE may participate in the pathogenic role of autoantibodies and the modulation of TACE expression by TNF-alpha antagonists might contribute to the beneficial effect of these drugs in inflammatory and autoimmune diseases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell salivary gland epithelial cell Homo sapiens
-

General Information

General Information Comment Organism
physiological function anti-Ro/SSA autoantibodies determine TACE pro-domain shedding suggesting that TACE activity is necessary for the release of TNF-alpha observed in anti-Ro/SSA autoantibody-stimulated cells. Adalimumab appears to be significantly more efficacious than Etanercept in preventing TACE activation caused by anti-Ro/SSA autoantibodies. Regulation of TACE may participate in the pathogenic role of autoantibodies and the modulation of TACE expression by TNF-alpha antagonists might contribute to the beneficial effect of these drugs in inflammatory and autoimmune diseases Homo sapiens