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Literature summary for 3.4.24.86 extracted from

  • Deng, X.; Lu, J.; Lehman-McKeeman, L.D.; Malle, E.; Crandall, D.L.; Ganey, P.E.; Roth, R.A.
    p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine (2008), J. Pharmacol. Exp. Ther., 326, 144-152.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide lipopolysaccharide-vehicle or lipopolysaccharide-ranitidine treatments of rats causes a significant increase in hepatic TACE activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
BMS-561392 TACE inhibitor also named DPC-333 is administered 15 min before ranitidine or its vehicle. Serum TNF-alpha concentration are measured 1 h afterwards. lipopolysaccharide/ranitidine treatment causes a significant increase in serum TNF-alpha concentration compared with lipopolysaccharide/vehicle treatment. Inhibitor does not affect serum TNF-alpha concentration after lipopolysaccharide/vehicle treatment. By contrast, it decreases serum TNF-alpha concentration after lipopolysaccharide/ranitidine treatment to the same level as lipopolysaccharide/vehicle treatment at both 1 h. In addition, TACE inhibitor decreases plasma active plasminogen activator inhibitor-1 concentration after lipopolysaccharide/ranitidine treatment to almost the same level as lipopolysaccharide/vehicle treatment Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
TNF-alpha + H2O Rattus norvegicus ranitidine enhances TNF-alpha production after lipopolysaccharide treatment through augmented p38 activation, and this seems to occur through TACE ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification TACE cleaves proTNF-alpha in its active form Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
TNF-alpha + H2O ranitidine enhances TNF-alpha production after lipopolysaccharide treatment through augmented p38 activation, and this seems to occur through TACE Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
TACE
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 Rattus norvegicus