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Literature summary for 3.4.24.86 extracted from

  • Serwin, A.B.; Sokolowska, M.; Dylejko, E.; Chodynicka, B.
    Tumour necrosis factor (TNF-alpha) alpha converting enzyme and soluble TNF-alpha receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption (2008), J. Eur. Acad. Dermatol. Venereol., 22, 712-717.
    View publication on PubMed

Application

Application Comment Organism
medicine in this study the relationship between long-term alcohol consumption and the concentration of TACE in peripheral blood mononuclear cells and its substrate- soluble TNF-alpha receptor type 1 in plasma in psoriasis patients is analysed. The study is conducted among 44 patients (aged 30-59 years) with early-onset, plaque-type psoriasis. 38 patients (aged 29-61 years) with other than psoriasis chronic dermatologic disorders are controls. The data on alcohol consumption during previous 10 years are obtained with a structured questionnaire. The severity of the disease is assessed using Psoriasis Area and Severity Index (PASI), and concentrations of TACE in peripheral blood mononuclear cells lysate and soluble TNF-alpha receptor type 1 in plasma is assessed with a quantitative sandwich enzyme immunoassay technique. The alcohol abuse contributes to the increase of TACE expression in blood mononuclear cells and also to the elevated plasma soluble TNF-alpha receptor type 1 concentration in psoriasis patients Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
soluble TNF-alpha receptor type 1 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TACE
-
Homo sapiens