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Literature summary for 3.4.24.86 extracted from

  • Tsakadze, N.L.; Sithu, S.D.; Sen, U.; English, W.R.; Murphy, G.; DSouza, S.E.
    Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1) (2006), J. Biol. Chem., 281, 3157-3164.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
intercellular adhesion molecule-1 + H2O Mus musculus ADAM-17 mediates shedding of intercellular adhesion molecule-1. The shedding of intercellular adhesion molecule-1 reduces the adhesive capacity of the cells. the cleavage site in the intercellular adhesion molecule-1 is not sequence-specific, but appears to be nonselective ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
intercellular adhesion molecule-1 + H2O
-
Mus musculus ?
-
?
intercellular adhesion molecule-1 + H2O ADAM-17 mediates shedding of intercellular adhesion molecule-1. The shedding of intercellular adhesion molecule-1 reduces the adhesive capacity of the cells. the cleavage site in the intercellular adhesion molecule-1 is not sequence-specific, but appears to be nonselective Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
ADAM-17
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Mus musculus
TACE
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Mus musculus