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Literature summary for 3.4.24.86 extracted from
- Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme (2001), Bioorg. Med. Chem. Lett., 11, 2907-2910.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | over-expression of TNF-alpha has been implicated in diseases such as rheumatoid arthritis, Crohn's disease, septic shock, AIDS, insulin resistance, cachexia and cancer | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| macrocyclic hydroxamic acid | - |
Homo sapiens |  |
| MMP-1 | - |
Homo sapiens | |
| MMP-2 | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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