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Literature summary for 3.4.24.86 extracted from
- TNF.alpha. converting enzyme (1999), Metalloproteinases as targets for anti-inflammatory drugs, (Bottomley, K. M. K; Bradshaw, D. ; Nixon, J. S. eds. ), , 187-203.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA encoding TACE, full-length human TACE, inefficiently expressed in insect cells, baculovirus particles in Sf9 cell line from Spodoptera frugiperda | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GW1988 | - |
Homo sapiens | |
| GW9471 | - |
Homo sapiens |  |
| GW9471 | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cytoplasmic tail | Mus musculus | 5737 | - |
| cytoplasm | cytoplasmic tail | Homo sapiens | 5737 | - |
| membrane | - |
Mus musculus | 16020 | - |
| membrane | microsomal membrane, transmembrane domain | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloprotease | Mus musculus | |
| Zn2+ | zinc metalloprotease | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | 100000 | sucrose density gradient centrifugation | Mus musculus |
| 85000 | - |
glycerol gradient, gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Homo sapiens | - |
MonoMac 6 cells | - |
| Mus musculus | - |
- |
- |
| Mus musculus | - |
mouse | - |
| Mus musculus C3H/HEN | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | - |
Mus musculus | - |
| monocyte | - |
Homo sapiens | - |
| spleen | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus C3H/HEN | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus C3H/HEN | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H-TACE | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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