Literature summary for 3.4.24.86 extracted from

Milla, M.E.; Leesnitzer, M.A.; Moss, M.L.; Clay, W.C.; Carter, H.L.; Miller, A.B.; Su, J.L.; Lambert, M.H.; Willard, D.H.; Sheeley, D.M.; Kost, T.A.; Burkhart, W.; Moyer, M.; Blackburn, R.K.; Pahel, G.L.; Mitchell, J.L.; Hoffman, C.R.; Becherer, J.D.
Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE) (1999), J. Biol. Chem., 274, 30563-30570.

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Application

Application	Comment	Organism
medicine	targeting this key enzyme for therapeutic intervention in inflammatory diseases, cancer and AIDS	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cDNA encoding TACE, full-length human TACE, inefficiently expressed in insect cells, baculovirus particles in Sf9 cell line from Spodoptera frugiperda	Homo sapiens

General Stability

General Stability	Organism
extreme salt sensitivity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
APMA	inhibits TACE completely	Homo sapiens
GW9471	hydroxamic acid competitive inhibitor that totally blocks TACE activity	Homo sapiens
NaCl	dramatic inhibitory effect on the activity of TACE	Homo sapiens
TACE-pro domain	pro domain is an inhibitor of the catalytic domain	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	cytosolic tail of TACE precedes TACE activation	Homo sapiens	5829	-
membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
TNF-alpha + H2O	Homo sapiens	-	soluble TNF-alpha	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-
Homo sapiens	-	MonoMac 6 cells	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
monocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proTNF-alpha + H2O	-	Homo sapiens	soluble TNF-alpha	release of proTNFalpha from cellular membranes	?
TNF-alpha + H2O	-	Homo sapiens	soluble TNF-alpha	-	?
transforming growth factor alpha + H2O	-	Homo sapiens	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
5	-	NaCl	-	Homo sapiens

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Release 2023.1 (January 2023)