Application | Comment | Organism |
---|---|---|
medicine | tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor, activating TACE by pharmacological manipulation might prove beneficial in Alzheimer's disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Immunex compound 3 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
TNF-alpha + H2O | Mus musculus | - |
soluble TNF-alpha | - |
? | |
TNF-alpha + H2O | Homo sapiens | membrane-bound tumor necrosis factor alpha undergoes proteolysis | soluble TNF-alpha | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
embryo | - |
Homo sapiens | - |
fibroblast | - |
Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
proTNF-alpha + H2O | membrane-bound tumor necrosis factor alpha undergoes proteolysis | Homo sapiens | soluble TNF-alpha | - |
? | |
TNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
TNF-alpha + H2O | membrane-bound tumor necrosis factor alpha undergoes proteolysis | Homo sapiens | soluble TNF-alpha | - |
? | |
transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? |