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Literature summary for 3.4.24.85 extracted from

  • Miyake, T.; Hizukuri, Y.; Akiyama, Y.
    Involvement of a membrane-bound amphiphilic helix in substrate discrimination and binding by an Escherichia coli S2P peptidase RseP (2020), Front. Microbiol., 11, 607381.
    View publication on PubMed
Search for more literature for 3.4.24.85

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Escherichia coli 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RseA + H2O Escherichia coli the enzyme is involved in the regulation of an extracytoplasmic stress response through the cleavage of membrane-spanning anti-stress-response transcription factor (anti-sigmaE) protein RseA. Extracytoplasmic stresses trigger a sequential cleavage of RseA, in which first DegS cleaves off its periplasmic domain, and RseP catalyzes the second cleavage of RseA. The two tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP serve as a size-exclusion filter which prevents the access of an intact RseA into the active site of RseP IMP domain. A periplasmic region of RseP, located downstream of the PDZ tandem domain, contains a segment (named H1) that acts as an adaptor required for proper arrangement of the PDZ tandem domain to perform its filter function and for substrate positioning for its efficient cleavage ?
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 ?
RseA + H2O Escherichia coli K12 the enzyme is involved in the regulation of an extracytoplasmic stress response through the cleavage of membrane-spanning anti-stress-response transcription factor (anti-sigmaE) protein RseA. Extracytoplasmic stresses trigger a sequential cleavage of RseA, in which first DegS cleaves off its periplasmic domain, and RseP catalyzes the second cleavage of RseA. The two tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP serve as a size-exclusion filter which prevents the access of an intact RseA into the active site of RseP IMP domain. A periplasmic region of RseP, located downstream of the PDZ tandem domain, contains a segment (named H1) that acts as an adaptor required for proper arrangement of the PDZ tandem domain to perform its filter function and for substrate positioning for its efficient cleavage ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AEH1
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Escherichia coli K12 P0AEH1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RseA + H2O the enzyme is involved in the regulation of an extracytoplasmic stress response through the cleavage of membrane-spanning anti-stress-response transcription factor (anti-sigmaE) protein RseA. Extracytoplasmic stresses trigger a sequential cleavage of RseA, in which first DegS cleaves off its periplasmic domain, and RseP catalyzes the second cleavage of RseA. The two tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP serve as a size-exclusion filter which prevents the access of an intact RseA into the active site of RseP IMP domain. A periplasmic region of RseP, located downstream of the PDZ tandem domain, contains a segment (named H1) that acts as an adaptor required for proper arrangement of the PDZ tandem domain to perform its filter function and for substrate positioning for its efficient cleavage Escherichia coli ?
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 ?
RseA + H2O
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 Escherichia coli ?
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 ?
RseA + H2O the enzyme is involved in the regulation of an extracytoplasmic stress response through the cleavage of membrane-spanning anti-stress-response transcription factor (anti-sigmaE) protein RseA. Extracytoplasmic stresses trigger a sequential cleavage of RseA, in which first DegS cleaves off its periplasmic domain, and RseP catalyzes the second cleavage of RseA. The two tandem-arranged periplasmic PDZ (PDZ tandem) domains of RseP serve as a size-exclusion filter which prevents the access of an intact RseA into the active site of RseP IMP domain. A periplasmic region of RseP, located downstream of the PDZ tandem domain, contains a segment (named H1) that acts as an adaptor required for proper arrangement of the PDZ tandem domain to perform its filter function and for substrate positioning for its efficient cleavage Escherichia coli K12 ?
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 ?
RseA + H2O
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 Escherichia coli K12 ?
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 ?

Synonyms

Synonyms Comment Organism
RseP
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 Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme is involved in the regulation of an extracytoplasmic stress response through the cleavage of membrane-spanning anti-stress-response transcription factor (anti-sigmaE) protein RseA Escherichia coli