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Literature summary for 3.4.24.85 extracted from

  • Gu, Y.; Lee, W.; Shen, J.
    Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells (2014), Sci. Rep., 4, 6268.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
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 Cricetulus griseus
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Expression

Organism Comment Expression
Cricetulus griseus oxidative stress significantly up-regulates site-2 protease expression in CHO cells up

General Information

General Information Comment Organism
physiological function cells defective in the site-2 protease gene have remarkably higher level of superoxide and elevated rates of cell death than wild-type CHO cells. Lack of the site-2 proease gene leads to cells more vulnerable to oxidative stress. Compared with wild-type CHO cells, mutant cells have higher nicotinamide adenine dinucleotide phosphate oxidase activity and lower paraoxonase-2 expression Cricetulus griseus