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Literature summary for 3.4.24.85 extracted from

  • Gu, Y.; Lee, W.; Shen, J.
    Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells (2014), Sci. Rep., 4, 6268.
    View publication on PubMed
Search for more literature for 3.4.24.85

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
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 Cricetulus griseus
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Expression

Organism Comment Expression
Cricetulus griseus oxidative stress significantly up-regulates site-2 protease expression in CHO cells up

General Information

General Information Comment Organism
physiological function cells defective in the site-2 protease gene have remarkably higher level of superoxide and elevated rates of cell death than wild-type CHO cells. Lack of the site-2 proease gene leads to cells more vulnerable to oxidative stress. Compared with wild-type CHO cells, mutant cells have higher nicotinamide adenine dinucleotide phosphate oxidase activity and lower paraoxonase-2 expression Cricetulus griseus