Literature summary for 3.4.24.83 extracted from

Ouyang, W.; Torigoe, C.; Fang, H.; Xie, T.; Frucht, D.
Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1alpha and causes decreased tolerance to hypoxic stress (2014), J. Biol. Chem., 289, 4180-4190.

Search for more literature for 3.4.24.83

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

General Information

General Information	Comment	Organism
physiological function	in mice treated with Anthrax lethal factor, serum lactate levels are reduced. Lethal factor inhibits the accumulation of hypoxia-inducible factor HIF-1alpha, a subunit of HIF-1, the master regulator directing cellular responses to hypoxia. The toxin has no effect on the transcription or protein turnover of HIF-1LPH, but inhibits HIF-1alpha translation. Lethal factor treatment diminishes phosphorylation of eIF4B, eIF4E, and rpS6, critical components of the intracellular machinery required for HIF-1alpha translation. Lethal factor treatment decreases the survival of hepatocyte cell lines grown in hypoxic conditions, an effect that is overcome by preinduction of HIF-1alpha	Bacillus anthracis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)