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Literature summary for 3.4.24.83 extracted from

  • Raymond, B.; Ravaux, L.; Memet, S.; Wu, Y.; Sturny-Leclere, A.; Leduc, D.; Denoyelle, C.; Goossens, P.L.; Paya, M.; Raymondjean, M.; Touqui, L.
    Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A(2) expression through MAPK/NF-kappaB inactivation (2010), Biochem. Pharmacol., 79, 1149-1155.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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General Information

General Information Comment Organism
physiological function secreted type-IIA phospholipase A2sPLA2-IIA expression is induced via a sequential MAPK-NF-kappaB activation and anthrax lethal toxin inhibits this expression likely by interfering with the transactivation of NF-kappaB in the nucleus. Anthrax lethal toxin inhibits IL-1b-induced p38 phosphorylation as well as sPLA2-IIA promoter activity in CHO cells. Inhibition of sPLA2-IIA promoter activity is mimicked by co-transfection with dominant negative construct of p38 and reversed by the active form of p38-MAPK. Both anthrax lethal toxin and the dominant negative construct of p38 decrease IL-1b-induced NF-kappaB luciferase activity. Neither anthrax lethal toxin nor specific p-38 inhibitor interfere with LPS-induced IkappaBalpha degradation or NF-kappaB nuclear translocation in guinea pig alveolar macrophages. Subcutaneous administration of anthrax lethal toxin to guinea pig before LPS challenge reduces sPLA2-IIA levels in broncho-alveolar lavages and ear Bacillus anthracis