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Literature summary for 3.4.24.83 extracted from
- Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple species (2008), Clin. Vaccine Immunol., 15, 946-953.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the anthrax lethal toxin neutralization assay (TNA) measures the ability of antibodies to neutralize the cytotoxicity of anthrax lethal toxin rather than quantifying total antibody through a conjugated species-specific secondary antibody. TNA may provide a more relevant immunological measure, as it quantitates functional antibodies only rather than total protective antigen-binding antibodies. In this study, TNA data are generated in several different laboratories to measure the immune responses in rabbits, nonhuman primates, and humans. A collaborative study is conducted in which 108 samples from the three species are analyzed in seven independent laboratories. This study demonstrates that the TNA is a panspecies assay that can be performed in several different laboratories with a high degree of quantitative agreement and precision | Bacillus anthracis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| anthrax lethal toxin | - |
Bacillus anthracis |
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