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Literature summary for 3.4.24.83 extracted from

  • Gaddis, B.D.; Rubert Perez, C.M.; Chmielewski, J.
    Inhibitors of anthrax lethal factor based upon N-oleoyldopamine (2008), Bioorg. Med. Chem. Lett., 18, 2467-2470.
    View publication on PubMed
Search for more literature for 3.4.24.83

Inhibitors

Inhibitors Comment Organism Structure
(9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide
-
 Bacillus anthracis
(9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
-
 Bacillus anthracis
N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide
-
 Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitogen activated protein kinase kinase + H2O
-
 Bacillus anthracis ?
-
 ?

Synonyms

Synonyms Comment Organism
lethal factor
-
 Bacillus anthracis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Bacillus anthracis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bacillus anthracis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0022
-
 (9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide
-
 Bacillus anthracis
0.003
-
 (9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
-
 Bacillus anthracis
0.0062
-
 N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide
-
 Bacillus anthracis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
-
 Bacillus anthracis (9Z)-N-(3,4-dihydroxybenzyl)octadec-9-enamide
0.015
-
-
 Bacillus anthracis (9Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
0.042
-
-
 Bacillus anthracis N-hydroxy-4-[[(9Z)-octadec-9-enoylamino]methyl]benzamide