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Literature summary for 3.4.24.82 extracted from
- ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro (2014), J. Histochem. Cytochem., 62, 34-49.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| podosome | ADAMTS-4 is present in f-actin- and cortactin-positive podosome-like puncta in single cells and mature tubes | Homo sapiens | 2102 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q75173 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HUVEC cell | ADAMTS-4 mRNA is relatively abundant in tubulogenic and control HUVEC cultures. Both mRNA and protein are significantly elevated in tubulogenic cultures versus controls | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biglycan + H2O | - |
Homo sapiens | ? | ADAMTS-4 and its substrate biglycan are involved in tubulogenesis by endothelial cells | ? |  |
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