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Literature summary for 3.4.24.82 extracted from
- Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides (2012), Arthritis Rheumatol., 64, 187-197.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | - |
Bos taurus | - |
| chondrocyte | - |
Bos taurus | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bos taurus | disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | disruptive changes in chondrocyte-matrix interactions by hyaluran oligosaccharides induce matrix degradation and elevate aggrecanases ADAMTS4, ADAMTS5 via the activation of the NF-kappaB signaling pathway | Bos taurus |
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Release 2023.1 (January 2023)
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