Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ADAMTS-4 binds to vascular endothelial growth factor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
a disintegrin and metalloproteinase with thrombospondin motifs-4 | - |
Homo sapiens |
ADAMTS-4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ADAMTS-4 inhibits human dermal microvascular endothelial cells (HuDMEC) vascular endothelial growth factor-stimulated vascular endothelial growth factor receptor R2 phosphorylation in a dose-related manner to give a maximum of about 65% inhibition at and above 30 nM. ADAMTS-4 reduces HuDMEC differentiation and migration | Homo sapiens |