Literature summary for 3.4.24.82 extracted from

Cheung, K.S.; Hashimoto, K.; Yamada, N.; Roach, H.I.
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation (2009), Rheumatol. Int., 29, 525-534.

Search for more literature for 3.4.24.82

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	increased gene expression is result of DNA methylation, resulting in heritable and permanent expression of ADAMTS-4 in osteoarthritis chondrocytes	Homo sapiens
additional information	increasing osteoarthritis severity results in increased number of ADAMTS-4 producing chondrocytes and in increased depth at which these chondrocytes are found, in healty cartilage ADAMTS-4 producing chondrocytes only in little numbers and located near the surface	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75173	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
articular cartilage	healthy humans or humans with osteoarthritis	Homo sapiens	-
chondrocyte	degradative chondrocytes express ADAMTS-4	Homo sapiens	-
femur	femoral head	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ADAMTS-4	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)