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Literature summary for 3.4.24.82 extracted from
- Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes (2009), Ann. Rheum. Dis., 68, 1051-1058.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1alpha | induced gene expression in osteoarthritic chondrocytes | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hyaluronan | hyaluronan 800 kDA and 2700 kDa decreased IL1alpha-induced expression of aggrecanase-1 decreased | Homo sapiens |  |
| KB-R7785 | - |
Homo sapiens | |
| TIMP3 | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| articular cartilage | - |
Homo sapiens | - |
| chondrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | 100 microg/ml | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS4 | - |
Homo sapiens |
| aggrecanase-1 | - |
Homo sapiens |
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