Literature summary for 3.4.24.82 extracted from

El Mabrouk, M.; Sylvester, J.; Zafarullah, M.
Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes (2007), Biochim. Biophys. Acta, 1773, 309-320.

Search for more literature for 3.4.24.82

Activating Compound

Activating Compound	Comment	Organism	Structure
interleukin-1beta	10 ng/ml	Homo sapiens
oncostatin M	dose-depedent stimulation of expression, 1-100 ng/ml	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
AG490	0.01 mM	Homo sapiens
Janus kinase 2 inhibitor	10 g/ml	Homo sapiens
Janus kinase 3 inhibitor	30 g/ml	Homo sapiens
LY294002	0.01 mM, reduces ADAMTS-4 expression	Homo sapiens
NL-71-101	0.02 mM, reduces ADAMTS-4 expression	Homo sapiens
parthenolide	0.005 mM, reduces ADAMTS-4 expression	Homo sapiens
phosphatidylinositol 3-kinase	reduces ADAMTS-4 expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrocyte	articular chondrocyte	Homo sapiens	-
SW-1353 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	-	Homo sapiens	fragments of aggrecan	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase with thrombospondin motifs-4	-	Homo sapiens
ADAMTS-4	-	Homo sapiens
aggrecanase-1	-	Homo sapiens

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Release 2023.1 (January 2023)