Literature summary for 3.4.24.82 extracted from

Wagsaeter, D.; Bjoerk, H.; Zhu, C.; Bjoerkegren, J.; Valen, G.; Hamsten, A.; Eriksson, P.
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques (2008), Atherosclerosis, 196, 514-522.

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Activating Compound

Activating Compound	Comment	Organism	Structure
interferon gamma	-	Homo sapiens
additional information	expression is not stimulated by interleukin-1beta	Homo sapiens
tissue necrosis factor alpha	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	low expression in non-atherosclerotic aorta	Homo sapiens	-
atherosclerotic carotid plaque	-	Homo sapiens	-
coronary atherosclerotic plaque	-	Homo sapiens	-
macrophage	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecanase 1	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase with thrombospondin motifs-4	-	Homo sapiens
ADAMTS-4	-	Homo sapiens
aggrecanase 1	-	Homo sapiens

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Release 2023.1 (January 2023)