Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14672 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
discoidin domain receptor 1 + H2O | - |
Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | collagen binding induces ADAM10-dependent ectodomain shedding of discoidin domain receptor DDR1. DDR1 shedding is not a result of an activation of its signaling pathway, since DDR1 mutants defective in signaling are shed in an efficient manner. DDR1 and ADAM10 are in a complex on the cell surface, but shedding does not occur unless collagen binds to DDR1. ADAM10-dependent DDR1 shedding regulates the half-life of collagen-induced phosphorylation of the receptor | Homo sapiens |