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Literature summary for 3.4.24.81 extracted from

  • Shitomi, Y.; Thogersen, I.; Ito, N.; Leitinger, B.; Enghild, J.; Itoh, Y.
    ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1) (2015), Mol. Biol. Cell, 26, 659-673.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens O14672
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
discoidin domain receptor 1 + H2O
-
Homo sapiens ?
-
?

General Information

General Information Comment Organism
physiological function collagen binding induces ADAM10-dependent ectodomain shedding of discoidin domain receptor DDR1. DDR1 shedding is not a result of an activation of its signaling pathway, since DDR1 mutants defective in signaling are shed in an efficient manner. DDR1 and ADAM10 are in a complex on the cell surface, but shedding does not occur unless collagen binds to DDR1. ADAM10-dependent DDR1 shedding regulates the half-life of colla­gen-induced phosphorylation of the receptor Homo sapiens