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Literature summary for 3.4.24.81 extracted from
- ADAM10 regulates notch function in intestinal stem cells of mice (2014), Gastroenterology, 147, 822-834.e13.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | intestinal stem cell | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | loss of ADAM10 from developing and adult intestine causes lethality associated with altered intestinal morphology, reduced progenitor cell proliferation, and increased secretory cell differentiation. ADAM10 deletion leads to the replacement of intestinal cell progenitors with post-mitotic, secretory cell lineages: intermediate-like and enteroendocrine cells. ADAM10 controls these cell fate decisions by regulating Notch signaling. ADAM10 is required for survival of Lgr5+ crypt-based columnar cells | Mus musculus |
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