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Literature summary for 3.4.24.81 extracted from

  • Janes, P.W.; Wimmer-Kleikamp, S.H.; Frangakis, A.S.; Treble, K.; Griesshaber, B.; Sabet, O.; Grabenbauer, M.; Ting, A.Y.; Saftig, P.; Bastiaens, P.I.; Lackmann, M.
    Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10 (2009), PLoS Biol., 7, e1000215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ADAM10 cleaves ephrin from its membrane tether on the opposite cell (through its so-called sheddase activity), thereby separating the cell-cell connection and allowing the signalling complex to internalise. Ephrin-A5 shedding by ADAM10 is controlled by steric hindrance exerted by the membrane-proximal EphA3 kinase domain, which prevents the functional interaction with ADAM10 that is needed for efficient substrate (ephrin) cleavage to occur Mus musculus ?
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General Information

General Information Comment Organism
physiological function ADAM10 cleaves ephrin from its membrane tether on the opposite cell (through its so-called sheddase activity), thereby separating the cell-cell connection and allowing the signalling complex to internalise. Ephrin-A5 shedding by ADAM10 is controlled by steric hindrance exerted by the membrane-proximal EphA3 kinase domain, which prevents the functional interaction with ADAM10 that is needed for efficient substrate (ephrin) cleavage to occur Mus musculus