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Literature summary for 3.4.24.81 extracted from

  • Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
    Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17 (2010), Immunology, 130, 83-91.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
FcalphaR + H2O Homo sapiens FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FcalphaR + H2O FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR Homo sapiens ?
-
 ?
FcalphaR + H2O FcaR (CD89) is the Fc receptor for immunoglobulin A Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
malfunction knockdown of both endogenous ADAM10 and endogenous ADAM17 inhibits FcalphaR shedding, demonstrating that ADAM10 and ADAM17 are involved in the shedding of FcalphaR Homo sapiens