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Literature summary for 3.4.24.81 extracted from
- Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin (2009), FASEB J., 23, 1643-1654.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GI254023X | ADAM10-specific inhibitor | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| SH-SY5Y cell | - |
Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | retinoids induce gene expression of ADAM10. The vitamin A analog acitretin stimulates ADAM10 promoter activity with an EC50 of 0.0015 mM | up |
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