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Literature summary for 3.4.24.81 extracted from

  • Raucci, A.; Cugusi, S.; Antonelli, A.; Barabino, S.M.; Monti, L.; Bierhaus, A.; Reiss, K.; Saftig, P.; Bianchi, M.E.
    A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) (2008), FASEB J., 22, 3716-3727.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information mouse embryonic fibroblast cells deficient of ADAM10 are not able to produce cleaved RAGE (receptor for advanced glycation endproducts). Stable transfection of MEF deficient with a plasmid coding for mouse ADAM10 is able to rescue the phenotype Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
GI254023X inhibits RAGE (receptor for advanced glycation endproducts) cleavage Homo sapiens
GW280623X inhibits RAGE (receptor for advanced glycation endproducts) cleavage Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RAGE + H2O a soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by ADAM10 Mus musculus ?
-
 ?
RAGE + H2O a soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by ADAM10 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM10
-
 Mus musculus
ADAM10
-
 Homo sapiens