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Literature summary for 3.4.24.81 extracted from

  • Anders, A.; Gilbert, S.; Garten, W.; Postina, R.; Fahrenholz, F.
    Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases (2001), FASEB J., 15, 1837-1839.
    View publication on PubMed
Search for more literature for 3.4.24.81

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information consensus sequence RKKR mutated for NAQA resulting in no expression of mature protein Bos taurus
additional information ADAM10 mutant lacking the prodomain is inactive, the prodomain is probably involved in the maturation of the enzyme Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-RVKR-chloromethylketone 0.03 mM of this proprotein convertase inhibitor decreases the formation of the ADAM10 mature form Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-
plasma membrane
-
 Bos taurus 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000 64000 active form, amino-terminal sequencing Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein Homo sapiens
-
 sAPP-alpha fragment + C-terminal fragment
-
 ?
beta-amyloid precursor protein Bos taurus
-
 sAPP-alpha fragment + C-terminal fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 caw
-
Homo sapiens
-
 cell line
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme has an inactive form that is activated by cleavage Bos taurus

Purification (Commentary)

Purification (Comment) Organism
SDS-PAGE Homo sapiens
SDS-PAGE Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
kidney cell line wild type cell line Homo sapiens
-
LoVo cell LoVo cell line does not express furin protease has both the immature and mature form of the enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein
-
 Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?
beta-amyloid precursor protein
-
 Bos taurus sAPP-alpha fragment + C-terminal fragment
-
 ?