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Literature summary for 3.4.24.80 extracted from

  • Feinberg, T.Y.; Rowe, R.G.; Saunders, T.L.; Weiss, S.J.
    Functional roles of MMP14 and MMP15 in early postnatal mammary gland development (2016), Development, 143, 3956-3968 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Protein Variants

Protein Variants Comment Organism
additional information MMP14 enzyme knockout in mammary gland epithelial cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Mus musculus 31012
-
membrane membrane-anchored Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus P53690
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-
adipocyte of mammary gland Mus musculus
-
brown fat
-
 Mus musculus
-
epithelial cell
-
 Mus musculus
-
mammary gland
-
 Mus musculus
-
mammary gland MMP15 transcriptome profiling, overview Mus musculus
-

Synonyms

Synonyms Comment Organism
membrane-anchored matrix metalloproteinase 14
-
 Mus musculus
MMP14
-
 Mus musculus
MT1-MMP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Mmp14-/- mice display defects in branching activity, phenotype, overview. Immunohistological assessments of Mmp14-/- mammary gland sections reveal no differences in the expression or organization of CK18, CK14, or alphaSMA from P0 through P10. MMP14 can activate MMP2 in vivo, a proteinase thought to mediate MMP14 function and to compensate partially for Mmp14 deficiency Mus musculus
metabolism branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. Different roles played by MMP14 or MMP15 in the mammary gland epithelial compartment and in development of mammary gland, overview. Whereas MMP14 promotes white fat-associated adipogenesis in the developing mammary gland, MMP15 serves as an endogenous suppressor of beige/brown fat production Mus musculus
physiological function metalloproteinase MMP14 (MT1-MMP) drives epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. It plays a role in mammary gland development. Transcriptome profiling reveals a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation. MMP14 promotes the generation of white fat depots crucial for energy storage. MMP14-dependent regulation of branching morphogenesis, overview. MMP14 can activate MMP2 in vivo, a proteinase thought to mediate MMP14 function and to compensate partially for Mmp14 deficiency. Early mammary gland branching proceeds independently of MMP14, MMP14-independent epithelial cell sorting, proliferation, senescence and extracellular matrix organization, overview Mus musculus