Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane proteinase | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
x * 58000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibroblast growth factor receptor-1 + H2O | Homo sapiens | - |
? | - |
? | |
fibroblast growth factor receptor-4 + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | the enzyme does not degrade fibroblast growth factor-2 or fibroblast growth factor receptor-2 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
KNS-42 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Res-186 cell | - |
Homo sapiens | - |
Res-259 cell | - |
Homo sapiens | - |
SF-188 cell | - |
Homo sapiens | - |
UW-479 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibroblast growth factor receptor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
fibroblast growth factor receptor-4 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme does not degrade fibroblast growth factor-2 or fibroblast growth factor receptor-2 | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 58000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
membrane-type I matrix metalloproteinase | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in tumor cells the enzyme downregulates fibroblast growth factor-2 signaling by reducing the amount of fibroblast growth factor-2 signaling bound to the cell surface with high and low affinity | Homo sapiens |