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Literature summary for 3.4.24.80 extracted from

  • Nishihara, T.; Remacle, A.; Angert, M.; Shubayev, I.; Shiryaev, S.; Liu, H.; Dolkas, J.; Chernov, A.; Strongin, A.; Shubayev, V.
    Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury (2015), J. Biol. Chem., 290, 3693-3707.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Inhibitors

Inhibitors Comment Organism Structure
DX2400 human monoclonal antibody Rattus norvegicus
tissue inhibitor of metalloproteinases-2
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Laminin + H2O Rattus norvegicus
-
 ?
-
 ?
neuronal glial antigen 2 + H2O Rattus norvegicus three (210, 160, and 51-52 kDa) major cleavage products are formed ?
-
 ?
pro-MMP-2 + H2O Rattus norvegicus
-
 MMP-2 + MMP-2 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q10739
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Schwann cell
-
 Rattus norvegicus
-
sciatic nerve
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-L-Pro-Leu-Gly-Leu-(3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O
-
 Rattus norvegicus ?
-
 ?
Gelatin + H2O
-
 Rattus norvegicus ?
-
 ?
Laminin + H2O
-
 Rattus norvegicus ?
-
 ?
neuronal glial antigen 2 + H2O three (210, 160, and 51-52 kDa) major cleavage products are formed Rattus norvegicus ?
-
 ?
pro-MMP-2 + H2O
-
 Rattus norvegicus MMP-2 + MMP-2 propeptide
-
 ?

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
 Rattus norvegicus
MT1-MMP/MMP-14
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction MT1-MMP inhibition restores sensory axon regeneration and attenuates hypersensitivity caused by peripheral nerve injury Rattus norvegicus
physiological function both neuronal glial antigen 2 shedding and axonal growth depend on the pericellular remodeling executed by MT1-MMP/MMP-14 Rattus norvegicus