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Literature summary for 3.4.24.80 extracted from

  • Nguyen, H.L.; Zucker, S.; Zarrabi, K.; Kadam, P.; Schmidt, C.; Cao, J.
    Oxidative stress and prostate cancer progression are elicited by membrane-type 1 matrix metalloproteinase (2011), Mol. Cancer Res., 9, 1305-1318.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
expressed in LNCaP cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E240A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-MMP-2 + H2O Homo sapiens
-
 MMP-2 + MMP-2 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
prostate gland cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
Laminin + H2O
-
 Homo sapiens ?
-
 ?
pro-MMP-2 + H2O
-
 Homo sapiens MMP-2 + MMP-2 propeptide
-
 ?

Synonyms

Synonyms Comment Organism
membrane-type 1 matrix metalloproteinase
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction membrane-type 1 matrix metalloproteinase knockdown in DU-145 cells decreases activity of reactive oxygen species 8-hydroxydeoxyguanosine Homo sapiens
physiological function oxidative stress and prostate cancer progression are elicited by membrane-type 1 matrix metalloproteinase Homo sapiens