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Literature summary for 3.4.24.80 extracted from

  • Crispi, S.; Calogero, R.A.; Santini, M.; Mellone, P.; Vincenzi, B.; Citro, G.; Vicidomini, G.; Fasano, S.; Meccariello, R.; Cobellis, G.; Menegozzo, S.; Pierantoni, R.; Facciolo, F.; Baldi, A.; Menegozzo, M.
    Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target (2009), PLoS ONE, 4, e7016.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Application

Application Comment Organism
diagnostics MMP-14 can be a biomarker in early development of mesothelioma tumours, overview Homo sapiens
drug development MMP-14 is an effective therapeutic target in therapy of mesothelioma tumours Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TIMP
-
 Homo sapiens
TIMP 4
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-MMP-2 + H2O Homo sapiens MMP14 is essential for proMMP-2 activation: pro-MMP-2 activation by MMP14/TIMP complex is realized in an environment of low TIMP concentration MMP-2 + MMP-2 propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMPs zymogen activation is strictly controlled by a membrane-associated event strictly connecting MT-MMP and MMP functions Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
pleural mesothelioma cell expression analysis of MMP-14 in pleural mesotheliomas compared to healthy pleural specimens, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-MMP-2 + H2O
-
 Homo sapiens MMP-2 + MMP-2 propeptide
-
 ?
pro-MMP-2 + H2O MMP14 is essential for proMMP-2 activation: pro-MMP-2 activation by MMP14/TIMP complex is realized in an environment of low TIMP concentration Homo sapiens MMP-2 + MMP-2 propeptide
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase 14
-
 Homo sapiens
MMP-14
-
 Homo sapiens
More MMP-14 is a member of matrix metalloproteinase family Homo sapiens

General Information

General Information Comment Organism
metabolism MMP-14 is involved in gene network of deregulated genes associated to cell cycle, overview Homo sapiens