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Literature summary for 3.4.24.80 extracted from

  • Kaner, R.J.; Santiago, F.; Crystal, R.G.
    Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema (2009), J. Leukoc. Biol., 86, 913-922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.80

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens membrane-type MMPs are membrane spanning binding sites that play an important role in the cell surface activation of MMPs such as MMP-2 ?
-
 ?
pro-MMP-2 + H2O Homo sapiens activation of MMP-2 mature MMP-12 + MMP-2 pro-peptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-14 is activated from a pro-MMP-14 form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial lining fluid
-
 Homo sapiens
-
lung HIV1- smokers with early emphysema have significantly higher relative expression of MMP-14 in comparison with HIV1- healthy smokers and HIV1- healthy nonsmokers. HIV1+ smokers with early emphysema also have significantly higher relative expression of alveolar mucosa MMP-14 in comparison with HIV1- normal smokers and HIV1- normal nonsmokers. There is no difference between the relative expression of alveolar mucosa MMP-14 between the HIV1- smokers with early emphysema and the HIV1+ smokers with early emphysema, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information membrane-type MMPs are membrane spanning binding sites that play an important role in the cell surface activation of MMPs such as MMP-2 Homo sapiens ?
-
 ?
pro-MMP-2 + H2O
-
 Homo sapiens mature MMP-12 + MMP-2 pro-peptide
-
 ?
pro-MMP-2 + H2O activation of MMP-2 Homo sapiens mature MMP-12 + MMP-2 pro-peptide
-
 ?

Synonyms

Synonyms Comment Organism
membrane-type MMP
-
 Homo sapiens
MMP-14
-
 Homo sapiens