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Literature summary for 3.4.24.80 extracted from

  • Gawden-Bone, C.; Zhou, Z.; King, E.; Prescott, A.; Watts, C.; Lucocq, J.
    Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14 (2010), J. Cell Sci., 123, 1427-1437.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information construction of MMP14 null B6 mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
podosome of immature dendritic cells. Podosomes are spot-like actin-rich structures formed at the ventral surface of monocytic and haematopoietic cells Mus musculus 2102
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Organism

Organism UniProt Comment Textmining
Mus musculus
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B6 mice
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Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
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Mus musculus
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hematopoietic cell
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Mus musculus
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monocyte
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Mus musculus
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Synonyms

Synonyms Comment Organism
MMP-14
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Mus musculus

General Information

General Information Comment Organism
physiological function podosomes mediate migration of dendritic cells through tissues by means of myosin-II-dependent protrusion coupled to MMP-14-dependent degradation and endocytosis. Degradation, protrusion and endocytosis in this system are dependent on the matrix metalloproteinase MMP-14 Mus musculus