Literature summary for 3.4.24.80 extracted from

Laudanski, P.; Swiatecka, J.; Kozlowski, L.; Lesniewska, M.; Wojtukiewicz, M.; Wolczynski, S.
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer (2010), Folia Histochem. Cytobiol., 48, 101-103.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-
plasma membrane	shedding of membrane-tethered MT1-MMP/MMP-14 from the cell surface	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	MT-MMPs have a unique regulatory mechanism in which an active enzyme undergoes a series of processing steps, either autocatalytic or mediated by other proteases, that regulate the activity and nature of the enzyme species at the cell surface and at the pericellular space	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
additional information	ductal breast cancer patients show 2fold increased serum MMP-14 levels compared to controls	Homo sapiens	-
serum	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
membrane type 1-matrix metalloproteinase	-	Homo sapiens
MMP-14	-	Homo sapiens
MT1-MMP	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	increased levels of soluble MT1-1/MMP-14 in the serum of breast cancer patients may have implications in the pathogenesis of the disease	Homo sapiens

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Release 2023.1 (January 2023)