Activating Compound | Comment | Organism | Structure |
---|---|---|---|
furin | activates proMT1-MMP, occurs intracellularly after exit from the Golgi apparatus and prior to its arrival at the plasma membrane | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | association of MT1-MMP with different membrane subdomains may be crucial in the control of its different activities like cell migration, invasion or MT1-MMP-dependent signaling pathways | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloned into a pcDNA3.0 expression vector | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-PDX | completely abats MT1-MMP-induced gelatin degradation by A375 cells | Homo sapiens | |
BB94 | maturation of MT1-MMP normally occurs | Homo sapiens | |
furin | inhibits MT1-MMP partitioning at the plasma membrane | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | 80% of MT1-MMP is sorted to detergent-resistant membrane fractions, only 20% of MT1-MMP from detergent-soluble fraction undergoes intracellular processing to the mature form, which is the sole form responsible for extracellular matrix degredation | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
immunoprecipitation, presumably fully processed mature form | Homo sapiens |
63000 | - |
immunoprecipitation, proMT1-MMP | Homo sapiens |
65000 | - |
immunoprecipitation, post-translationally modified unprocessed form, glycopeptidase F-resistant and also present if treated with inhibitors of N- and O-glycosylation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | A375 cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane type-1 matrix metalloprotease | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |