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Literature summary for 3.4.24.80 extracted from

  • Savinov, A.Y.; Rozanov, D.V.; Golubkov, V.S.; Wong, F.S.; Strongin, A.Y.
    Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas (2005), J. Biol. Chem., 280, 27755-27758.
    View publication on PubMed

Application

Application Comment Organism
medicine MT1-MMP proteolysis of T cell CD44 regulates adhesion and subsequent transmigration and homing of T cells into the pancreas, inhibition of T cell MT1-MMP is key to delaying the onset of diabetes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AG3340 inhibits MT1-MMP in a sub-nanomolar range Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information high levels of cell surface-associated MT1-MMP and CD44 in IS-CD8+ cells Mus musculus
-
T-cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD44 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
membrane type-1 matrix metalloproteinase
-
Mus musculus
MT1-MMP
-
Mus musculus