Application | Comment | Organism |
---|---|---|
medicine | MT1-MMP proteolysis of T cell CD44 regulates adhesion and subsequent transmigration and homing of T cells into the pancreas, inhibition of T cell MT1-MMP is key to delaying the onset of diabetes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG3340 | inhibits MT1-MMP in a sub-nanomolar range | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | high levels of cell surface-associated MT1-MMP and CD44 in IS-CD8+ cells | Mus musculus | - |
T-cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CD44 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane type-1 matrix metalloproteinase | - |
Mus musculus |
MT1-MMP | - |
Mus musculus |