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Literature summary for 3.4.24.80 extracted from
- Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis (2004), J. Biol. Chem., 279, 39042-39050.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TGF-beta1 | induces MT1-MMP expression and enhances its activity | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | complex reciprocal effects of ERK1/2 and p38 MAPK in the regulation of MT1-MMP activity, which may complicate the use of MAPK-specific inhibitors as therapeutic agents to down-regulate the biologic effects of TGF-beta1 on pericellular collagen degradation and tumor invasion | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GM6001 | blocks MT1-MMP autolytic processing | Homo sapiens |  |
| TIMP-2 | inhibitory interaction with the catalytically competent MT1-MMP active site, prevents autolytic processing | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
autolysis product, Western blot analysis | Homo sapiens |
| 55000 | - |
active enzyme, Western blot analysis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| squamous cell carcinoma cell | from the oral cavity, SCC9, SCC25 and SCC68 cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| membrane type 1-MMP | - |
Homo sapiens |
| MMP-14 | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
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