Literature summary for 3.4.24.80 extracted from

Uekita, T.; Itoh, Y.; Yana, I.; Ohno, H.; Seiki, M.
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity (2001), J. Cell Biol., 155, 1345-1356.

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Cloned(Commentary)

Cloned (Comment)	Organism
wild-type and various mutants: deletion of catalytic domain, deletion of POX domain, deletion of cytoplasmic tail, deletion of 8, 8 or 12 amino acids at C-terminus, all deletions except catalytic and PEX domain reduced internalization of the protein	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
L571A/L572A	mutation leads to reduced internalization of enzyme	Homo sapiens
L571A/L572A/L578A/L579A	mutation leads to reduced internalization of enzyme	Homo sapiens
L571A/L572A/Y573A	mutation leads to reduced internalization of enzyme, no effect on cell motility	Homo sapiens
L578A/L579A	mutation leads to reduced internalization of enzyme	Homo sapiens
S577A	internalization of enzyme is not affected, enhanced cell motility	Homo sapiens
V582A	internalization of enzyme is not affected	Homo sapiens
Y573A	mutation leads to reduced internalization of enzyme	Homo sapiens
Y573A/L571A/L572A/L578A/L579A	mutation leads to reduced internalization of enzyme	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	transmembrane protein	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	involved in cell migration	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50281	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	involved in cell migration	Homo sapiens	?	-	?
progelatinase A + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)