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Literature summary for 3.4.24.79 extracted from

  • Conover, C.
    Key questions and answers about pregnancy-associated plasma protein-A (2012), Trends Endocrinol. Metab., 23, 242-249.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.79

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloproteinase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor-binding protein-2 + H2O Homo sapiens
-
 ?
-
 ?
insulin-like growth factor-binding protein-4 + H2O Homo sapiens
-
 ?
-
 ?
insulin-like growth factor-binding protein-5 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13219
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
placenta placental syncytiotrophoblast Homo sapiens
-
syncytiotrophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor-binding protein-2 + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor-binding protein-4 + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor-binding protein-5 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PAPP-A
-
 Homo sapiens
pregnancy-associated plasma protein-A
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome. interferon-gamma decreases enzyme expression in human fibroblasts down
Homo sapiens enzyme expression in cultured human dermal fibroblasts, human coronary artery endothelial, osteoblasts, and smooth muscle cells is stimulated by tumor necrosis factor-alpha, interleukin-1beta, interleukin-4, and transforming growth factor-beta. Enzyme expression is upregulated in response to acute injury. Gene expression is induced by forskolin and prostaglandin E2 in human osteoblasts, by bone morphogenic protein-2 in human mesenchymal stem cells, and by follicle-stimulating hormone in bovine granulosa cells in culture up

General Information

General Information Comment Organism
malfunction enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome Homo sapiens
physiological function the enzyme can act as an autocrine/paracrine regulator of insulin-like growth factor action Homo sapiens