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Literature summary for 3.4.24.79 extracted from
- Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo (2011), Endocrinology, 152, 1470-1478.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in SKOV-3 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E483Q | he proteolytic activity of the mutant is markedly reduced | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| insulin-like growth factor binding protein + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13219 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| insulin-like growth factor binding protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAPP-A | - |
Homo sapiens |
| pregnancy-associated plasma protein-A | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | pregnancy-associated plasma protein-A (PAPP-A) acts to enhance tumor growth in vivo. Overexpression of PAPP-A favored development of mature tumor vasculature. PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells | Homo sapiens |
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Release 2023.1 (January 2023)
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