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Literature summary for 3.4.24.79 extracted from
- Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice (2007), J. Endocrinol., 192, 505-513.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of PAPP-A knockout mice, which show impaired post-fracture, bony bridging of a mid-shaft fracture callus, the mutant mice show reduced amount of intramembranous bone formation, cartilage production, endochondral ossification and remodeling compared to wild-type mice, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IGF-binding protein-4 + H2O | Mus musculus | i.e. IGFBP-4 | ? | - |
? |  |
| additional information | Mus musculus | pregnancy associated plasma protein-A is involved in regulation of IGF bioavailability and in skeletal development and injury repair, responses is necessary for expeditious fracture healing in mice, mechanism for PAPP-A regulation of IGF action, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| callus | of bone fracture in the mid-shaft | Mus musculus | - |
| osteoblast | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IGF-binding protein-4 + H2O | i.e. IGFBP-4 | Mus musculus | ? | - |
? | |
| additional information | pregnancy associated plasma protein-A is involved in regulation of IGF bioavailability and in skeletal development and injury repair, responses is necessary for expeditious fracture healing in mice, mechanism for PAPP-A regulation of IGF action, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAPP-A | - |
Mus musculus |
| pregnancy associated plasma protein-A | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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