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Literature summary for 3.4.24.79 extracted from

  • Laursen, L.S.; Overgaard, M.T.; Weyer, K.; Boldt, H.B.; Ebbesen, P.; Christiansen, M.; Sottrup-Jensen, L.; Giudice, L.C.; Oxvig, C.
    Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity (2002), J. Biol. Chem., 277, 47225-47234.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble PAPP-A reversibly binds to cell surface, while PAPP-A2 does not Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Reaction

Reaction Comment Organism Reaction ID
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 mechanism Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-5 + H2O cleavage by PAPP-A and PAPP-A2 Homo sapiens ?
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