Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IGF | PAPP-A activity is dependent on presence of insulin-like growth factor-II | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 | mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin-like growth factor binding protein-4 + H2O | mutants of insulin-like growth factor binding protein-4 | Homo sapiens | ? | - |
? | |
additional information | cleavage of insulin-like growth factor binding protein-4 occurs only in presence of insulin-like growth factor-II | Homo sapiens | ? | - |
? | |
additional information | interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis | Homo sapiens | ? | - |
? |