Any feedback?
Literature summary for 3.4.24.75 extracted from
- Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family (2017), Sci. Rep., 7, 6020 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is a potential antimicrobial agent for Staphylococcus aureus infections | Staphylococcus aureus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | binding of a second zinc ion effectively inhibits the enzyme | Staphylococcus aureus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Staphylococcus aureus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pentaglycine + H2O | Staphylococcus aureus | - |
diglycine + triglycine | - |
? | |
| pentaglycine + H2O | Staphylococcus aureus NCTC 8325 | - |
diglycine + triglycine | - |
? | |
| Staphylococcus aureus cell wall + H2O | Staphylococcus aureus | - |
? | - |
? | |
| Staphylococcus aureus cell wall + H2O | Staphylococcus aureus NCTC 8325 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
| Staphylococcus aureus NCTC 8325 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pentaglycine + H2O | - |
Staphylococcus aureus | diglycine + triglycine | - |
? | |
| pentaglycine + H2O | - |
Staphylococcus aureus NCTC 8325 | diglycine + triglycine | - |
? | |
| Staphylococcus aureus cell wall + H2O | - |
Staphylococcus aureus | ? | - |
? | |
| Staphylococcus aureus cell wall + H2O | - |
Staphylococcus aureus NCTC 8325 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LytU | - |
Staphylococcus aureus |
| peptidoglycan endopeptidase | - |
Staphylococcus aureus |
| sa0205 | - |
Staphylococcus aureus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
