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Literature summary for 3.4.24.74 extracted from
- Enterotoxigenic Bacteroides fragilis (2008), Curr. Infect. Dis. Rep., 10, 99-104.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene bft-1 | Bacteroides fragilis |
| gene bft-2 | Bacteroides fragilis |
| gene bft-3 | Bacteroides fragilis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Bacteroides fragilis | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloprotease toxin with a C-terminal zinc-binding protease domain | Bacteroides fragilis |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
x * 44000, preenzyme, x * 20000, mature enzyme | Bacteroides fragilis |
| 44000 | - |
x * 44000, preenzyme, x * 20000, mature enzyme | Bacteroides fragilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| actin + H2O | Bacteroides fragilis | - |
? | - |
? | |
| E-cadherin + H2O | Bacteroides fragilis | the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin | ? | - |
? | |
| Fibrinogen + H2O | Bacteroides fragilis | - |
? | - |
? | |
| additional information | Bacteroides fragilis | the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview | ? | - |
? | |
| additional information | Bacteroides fragilis | the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview | ? | - |
? | |
| myosinO | Bacteroides fragilis | - |
? | - |
? | |
| myosinO + H2O | Bacteroides fragilis | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteroides fragilis | O05091 | enterotoxigenic strains, isozyme Bft-2 encoded by gene bft-2 | - |
| Bacteroides fragilis | O86049 | enterotoxigenic strains, isozyme Bft-3 encoded by gene bft-3 | - |
| Bacteroides fragilis | Q9S5W0 | enterotoxigenic strains, isozyme Bft-1 encoded by gene bft-1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| actin + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| E-cadherin + H2O | the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin | Bacteroides fragilis | ? | - |
? | |
| E-cadherin + H2O | the enzyme hydrolyzes the extracellular domain of the substrate | Bacteroides fragilis | ? | - |
? | |
| Fibrinogen + H2O | - |
Bacteroides fragilis | ? | - |
? | |
| additional information | the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview | Bacteroides fragilis | ? | - |
? | |
| additional information | the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview | Bacteroides fragilis | ? | - |
? | |
| additional information | fragilysin is a zinc metalloprotease toxin with a C-terminal zinc-binding protease domain | Bacteroides fragilis | ? | - |
? | |
| myosinO | - |
Bacteroides fragilis | ? | - |
? | |
| myosinO + H2O | - |
Bacteroides fragilis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 44000, preenzyme, x * 20000, mature enzyme | Bacteroides fragilis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme is a member of the matrix metalloprotease family of proteins | Bacteroides fragilis |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
stable over a wide range | Bacteroides fragilis |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
stable over a wide range | Bacteroides fragilis |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Bacteroides fragilis | - |
- |
4.5 |
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