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Literature summary for 3.4.24.74 extracted from

  • Moncrief, J.S.; Obisco, R.; Barroso, L.A.; Kling, J.J.; Wright, R.L.; van Tassell, R.L.; Lyerly, D.M.; Wilkins, T.D.
    The enterotoxin of Bacteroides fragilis is a metalloprotease (1995), Infect. Immun., 63, 175-181.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.74

Cloned(Commentary)

Cloned (Comment) Organism
-
 Bacteroides fragilis

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Bacteroides fragilis
2,2'-dipyridyl
-
 Bacteroides fragilis
Alpha-macroglobulin moderate inhibitor Bacteroides fragilis
diethyldicarbonate moderate inhibitor Bacteroides fragilis
dithiothreitol
-
 Bacteroides fragilis
EDTA
-
 Bacteroides fragilis
additional information not inhibitory are phenylmethylsulfonylfluoride, 4-(2-aminoethyl)-benzenesulfonylfluoride, tosylamide-2-phenylethyl chloromethylketone, tosyl-Lys chloromethylketone Bacteroides fragilis
thimerosal i.e. sodium ethylmercurithiosalicylate Bacteroides fragilis
Zincov
-
 Bacteroides fragilis
Zn2+ 10 mM, slightly inhibitory Bacteroides fragilis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Bacteroides fragilis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metalloprotease, 1 gatom of Zn2+ per mol of enzyme Bacteroides fragilis

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture filtrate
-
 Bacteroides fragilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Actin + H2O initial cleavage at Gly-Met, followed by Thr-Leu Bacteroides fragilis Fragements of actin
-
 ?
Azocoll + H2O
-
 Bacteroides fragilis Fragements of azocoll
-
 ?
Fibrinogen + H2O hydrolysis to a lesser degree than other substrates Bacteroides fragilis Fragements of fibrinogen
-
 ?
Fragilysin + H2O autodigestion Bacteroides fragilis Fragements of fragilysisn
-
 ?
Gelatin + H2O
-
 Bacteroides fragilis Fragements of gelatin
-
 ?
Tropomyosin + H2O hydrolysis to a lesser degree than other substrates Bacteroides fragilis Fragements of tropomyosin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Bacteroides fragilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Bacteroides fragilis